Ubiquitin K48 Selector is based on a high-affinity single-domain antibody (sdAb) that is covalently immobilized on 4% cross-linked agarose beads.
Proteins in cells can be ubiquitinated where E3 ligase catalyzes the last step of this process. After conjugating the initial ubiquitin on the target protein, further ubiquitin proteins can be conjugated to the first ubiquitin resulting in a polyubiquitin chain. The conjugation of new ubiquitins to form a poly-chain happens at one of the seven lysines (K) present in ubiquitin. The addition of a new ubiquitin on the lysine at position 48 (K48) is a signal for the target protein to be sent to the proteasome for degradation.
Our sdAb binds most specifically to this K48 linkage on polyubiquitin chains.
This product was a co-development with
|Capacity:||> 2.5 µg K-48 linked Ubiquitin per µL of packed beads|
|Antigen:||Ubiquitin K48 linkage|
|Specificity:||Recognizes K48-linkages of polyubiquitin.|
|Formulation:||50% slurry in PBS containing 20% Ethanol|
|Storing:||Store at 4 °C for up to 12 months. Do not freeze!|
|Notice:||To be used in vitro/ for research only. Non-toxic, non-hazardous, non-infectious.|
|Legal terms:||By purchasing this product you agree to our general terms and conditions.|