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STED image of indirect immunostaining of PFA fixed mouse brain with FluoTag-X2 anti-PSD95 AbberiorSTAR 635P (cat. no. N3702-Ab635P-L).

sdAb anti-PSD95

Cat No: N3705 Category:

Price range: 290,00 € through 655,00 €

A single-domain antibody that specifically recognizes mouse and rat PSD95.

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Postsynaptic Density Protein 95 or PSD95 (alternative names: PSD-95, SAP-90 and DLG4) is a member of the MAGUK family, and it plays an essential role in forming a dynamic scaffold at the post-synapses. It functions as an organizing centrum of receptors, ion channels, kinases, and other relevant players in achieving synaptic plasticity and molecular changes during long-term potentiation.

Our nanobody binds selectively and strongly to PDZ domain 2 of PSD95, and it does not bind to either of its close family members, PSD93, SAP97 or SAP102. Its characterization was published in the Int J Mol Sci. 2023.

MSDS
sdAb unconjugated
sdAb-Biotin/DBCO
Protocols
Reconstitution and Storage
Variations:
Conjugation Amount Cat No. RRID
unconjugated C-terminal Cys 250 μg N3705-250ug AB_3076107
Biotin 250 μg N3705-Biotin AB_3076108
DBCO 250 μg N3705-DBCO AB_3076109
Related Products:

FluoTag®-X2 anti-PSD95 (Cat. No. N3702)

Recombinant anti-PSD95 antibody (rHcAb) (Cat. No. N3782 – N3785)

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Clone: 1B2
Host: Alpaca
Produced in: E.coli
Application: IF, IHC
Dilution: N/A
Capacity: N/A
Antigen: -
Targets: PSD95
Specificity: Validated to recognize an epitope within the PDZ2 domain of PSD95 in mouse and rat. Cross-reactivity with human PSD95 is predicted from sequence identity between the human and rat PDZ2 domains. Other species not explicitly addressed. Does not cross-react with PSD93, SAP97 or SAP102.
Formulation:

DBCO- and Biotin-conjugated sdAbs (1:1 labeling on the C-terminus) are lyophilized from PBS pH 7.4. Unconjugated sdAbs are lyophilized from 5 mM KPi pH 6.0, 300 mM NaCl, 0.5 mM EDTA pH 6.0. Reconstitute with 250 µL pure deionized water for immediate use or with 250 µL sterile 50% glycerol for storage at -80°C. For more details, click the Protocols button above and check Reconstitution and Storage.
kDa: 15.4
Ext Coef: 24138
Shipping: Ambient temperature
Storage:

Vials containing lyophilized reagent can be stored at 2-8°C for up to 12 months. After reconstitution, store at -80°C for up to 6 months. Working aliquots can be stored at -20°C for up to 4 weeks. For more details, click the Protocols button above and check Reconstitution and Storage.
Protocols:

Relevant protocols can be found under the Protocols button above. For additional information, visit our Resources page.
References:
  1. Unterauer EM, Schentarra EM, Jevdokimenko K, et al. Protocol for SUM-PAINT spatial proteomic imaging generating neuronal architecture maps in rat hippocampal neurons. STAR Protoc. 2025;6(1):103637. doi:10.1016/j.xpro.2025.103637 (ICC/IF; DNA-PAINT)
  2. Unterauer EM, Shetab Boushehri S, Jevdokimenko K, et al. Spatial proteomics in neurons at single-protein resolution. Cell. 2024;187(7):1785-1800.e16. doi:10.1016/j.cell.2024.02.045 (IF/ICC; DNA-PAINT)
Notice: To be used in vitro/ for research only. Non-toxic, non-hazardous, non-infectious.
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