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Ubiquitin pan Selector

Cat No: N2510 Category:

275,00 €

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Ubiquitin is a small protein of 76 amino acids present in the cell cytoplasm. It is presently ubiquitous in all eukaryotic cells, thus its name. There is a large research community studying various paths and different processes in which ubiquitin is believed to play a relevant role. One of the most notorious functions of ubiquitin is to tag defective proteins to be sent into the proteasome for degradation, vital for the maintenance of the cellular household.

Our sdAb recognizes the ubiquitin irrespective of its linkage to other subunits or its multimeric state. Thus, the Ubiquitin pan Selector captures most ubiquitin forms (monomeric and if part of poly chains).

This product was a co-development with

MSDS Protocols
Variations:
Conjugation Amount Cat No. RRID
4% cross-linked agarose 2000 μl N2510 AB_3076050
Related Products: -
Clone: E5-2
Host: Synthetic Library
Produced in: E.coli
Application: IP
Dilution: N/A
Capacity: > 2.5 µg Ubiquitin per µL of packed beads
Antigen: -
Targets: Ubiquitin (pan)
Specificity: ubiquitin, monomeric or any polyubiquitins
Formulation:

50% slurry in PBS containing 20% Ethanol
kDa: -
Ext Coef: -
Shipping: Ambient temperature
Storing:

Store at 4 °C for up to 12 months. Do not freeze!
Protocols: -
References:
  1. Amhaz S, Boëda B, Chouchène M, et al. The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia. BMC Biol. 2023;21(1):73. Published 2023 Apr 7. doi:10.1186/s12915-023-01576-4 (IP; tested species: human, HEK293, U2OS)
  2. Vdovin A, Jelinek T, Zihala D, et al. The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma. Nat Commun. 2022;13(1):6820. Published 2022 Nov 10. doi:10.1038/s41467-022-34654-2 (IP; tested species: human, HEK293)
  3. Leong JX, Raffeiner M, Spinti D, et al. A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component. EMBO J. 2022;41(13):e110352. doi:10.15252/embj.2021110352 (IP; tested species: Nicotiana benthamiana)
  4. Laigle V, Dingli F, Amhaz S, et al. Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-β Signaling Pathway. Mol Cell Proteomics. 2021;20:100173. doi:10.1016/j.mcpro.2021.100173 (IP; tested species: human, U2OS)
Notice: To be used in vitro/ for research only. Non-toxic, non-hazardous, non-infectious.
Legal terms: By purchasing this product you agree to our general terms and conditions.

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