Resolving bundled microtubules using anti-tubulin nanobodies

 

Here researchers demostrated that small probes like nanobodies can provide a high density of labeling and help achieving improved resolution with super-resolution microscopy (in this case they used STORM). This allowed them to distinguishing bundles of microtubules that were not able to be resolved using conventional antibodies.

Mikhaylova M, et. al. (2015). Nat Commun 6:7933